These complications included cerclage, a procedure to sew the entrance of the uterus shut to prevent preterm birth. 92.6% of 6WE patients did not have any complications, versus 54.5% of the comparison group. There were significantly fewer pregnancy complications for the 6WE group. The average blood levels of estradiol and progesterone were similar in the two groups. The other half continued taking both medications until 12 weeks after the FET.Īfter 12 weeks, the 6WE patients had a significantly lower miscarriage rate (3.13% vs. This group continued to take progesterone but stopped taking estradiol after 6 weeks. 32 patients were randomly assigned to the 6-week estrogen (6WE) group. After the FET, all patients received progesterone, and continued taking estradiol.Ħ weeks after the FET, 64 patients had a pregnancy visible on ultrasound. Then they received estradiol valerate to prepare the lining of the uterus. All of the patients had their body’s own hormone levels reduced using the GnRH agonist buserelin (Suprefact). This study recruited 291 patients who were undergoing FET using an artificial cycle. However, it is not clear how long estradiol should be used in artificial cycle FET. For women using artificial cycle FET, estradiol and progesterone are typically taken until 10 to 12 weeks. If the woman becomes pregnant, the developing placenta begins to release estrogen and progesterone around the fifth week. When using an artificial cycle, the ovary does not release its own progesterone. This hormone maintains the lining of the uterus. Estradiol is the type of estrogen used to prepare for a FET.Īround when the embryo is transferred, supplements of progesterone are used in addition to estradiol. One role of estrogen is to thicken the lining of the uterus. Estrogen is a hormone which is high in the early part of the menstrual cycle, and causes changes throughout the body. Alternately, artificial cycle FET uses injections of hormones including estrogen to prepare the uterus. During IVF treatment, a typical estrogen level will be less than 75 at the time of baseline evaluation and may get as high as 2,000 4,000 (in a normal. One way to do this is to time the FET for after ovulation when the uterus is receptive. In order for a FET to be successful, the lining of the uterus must be receptive to an embryo implanting. FET uses embryos preserved from an earlier cycle of in vitro fertilization (IVF). FET is a common infertility technique, in which a frozen embryo is transferred to the uterus.
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